Tuesday, January 5, 2016

Pharmacokinetic of common IR drugs

Midazolam (Versed): onset of action 3-5 minutes, half-life of 1-4 hours

Fentanyl: onset of action nearly immediate; duration of action is 30-60 minutes. 100 mcg of fentanyl equivalent to 10 mg morphine.

Alteplase: half-life is < 5 minutes

Heparin: half-life is 90 minutes

Ondansetron (Zofran): half-life is 5.7 hours

Flumazenil (Benzo-reversal): onset of action 1-2 minutes; initial dose is 0.2 mg IV over 15-30 seconds 

Naloxone (Opiate-reversal): onset of action 2 minutes; initial dose is 0.4-2mg, can give every 2-3 minutes